In the new trailer, it appears Stark has a shot at normalcy until The Mandarin (Ben Kingsley) wreaks havoc. "Do you want an empty life or meaningful death?" Seethes Kingsley as Stark's coastal home is destroy along with several Iron Man suits and Potts is kidnapped.
That appears to be the setup to the summer blockbuster, with the rest of the details only hinted at. Don Cheadle is back and will apparently be wearing the patriotic Iron Patriot suit. Dozens of "Iron Men" appear later at the same location for a climactic battle. We also get a glimpse of the Hulkbuster armor!