Academy Award winning actress Susan Sarandon returns to host "MADtv's Most Wanted" on Saturday, October 6 (11:00-Midnight ET/PT) on FOX.

Sarandon and MADtv's Michael McDonald pair up in New York City to present a night of fan-favorite sketches featuring cast members McDonald ("Stuart"), Alex Borstein ("Miss Swan"), Mo Collins ("Lorraine"), Keegan-Michael Key ("Coach Hines"), Stephnie Weir ("Dot") and Nicole Sullivan ("The Vancome Lady").