Bono, Benicio Del Toro and Spanish movie couple Penelope Cruz and Javier Bardem have teamed up for a star-studded new Lazarus Effect Campaign ad to raise awareness for medication in Africa.

The stars all show off silly items that can be bought for 40 cents - the daily price of pills that can help HIV sufferers stay alive.

In the campaign ad, Bono shows off a novelty hat, Cruz some bubble gum, Bardem lipstick and Del Toro a stamp.

"Glee" star Jane Lynch offers "helium" from a balloon, Julia Louis-Dreyfus a fake moustache, Orlando Bloom a balloon dog and rapper Ludacris a sheet of fabric softener in the quirky (Red) campaign ad.

A sombre Bono ends the clip by stating, "Two pills a day is what it takes to stay alive if you're HIV-positive. These pills cost about 40 cents a day."

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