"He makes really good music, he does," Lowe said in the interview for "Oprah Prime." "But I think he knows the dark secret, and the dark secret is that 80 percent of his audience doesn't give a s**t about his music. He knows it. It bums him out."
Lowe, who knows what it's like to be a young heartthrob, added, "They care about lemming-think, and their girlfriends and who's oohing and ahhing. It has nothing to do with what he's doing as an artist.
"He is the guy who's standing in front at a moment when they're going through a developmental thing. It's natural, it's all great, but if it wasn't him, it'd be someone else, like it was me."
Lowe was lucky. He was able to transform from a member of the 1980s "Brat Pack" and star in series such as "The West Wing," "Brothers & Sisters" and "Parks and Recreation."
The question is - will Bieber, 20, be able to maintain a successful career into adulthood?