New York City was buzzing last night with the cast of "Side Effects," who attended the film's premiere at the  AMC Lincoln Square Theatre.

Catherine Zeta-Jones looked like Hollywood royalty in a strapless black and nude printed dress by Michael Kors. She was accompanied by her husband Michael Douglas.

Rooney Mara wore a heavily embroidered white gown, and her sister Kate Mara wore a simple black frock to the event. Sexy Channing Tatum and Jude Law donned black and grey suits.

The film centers on Emily and Martin (Mara and Tatum) as a couple whose lives are shattered by a mysterious new prescription drug. Jude Law plays Emily's psychiatrist.

Check out more photos from the premiere...