The couple told People in a joint statement, "We will always love each other and be best friends, however, we have mutually decided to separate at this time."
Patton and Thicke married in 2005 and Patton gave birth to the couple's only child, Julian Fuego, in 2010.
Patton and Thicke's marriage was placed in the spotlight after Thicke's "Blurred Lines" hit it big and his infamous VMAs performance with Miley Cyrus. No less than three women were spotted with the singer, with at least one claiming Patton was around while he fondled her.
Rumors of cheating or an open marriage don't matter anymore. It remains to be seen how the couple will handle the support of their son and a divorce settlement.