Reese Witherspoon narrowly defeated America's sweetheart Jennifer Aniston to make it into this round and perhaps claim that very title from Jen. She battles aliens in her latest film, Monsters vs. Aliens, where she plays the voice of Ginormica, a giant woman. She's currently dating actor Jake Gyllenhaal.

Natalie Portman has starred in such films as V for Vendetta and the Star Wars prequel trilogy (1, 2, 3). Oh, and yeah, she just pulled off the upset of #1 seed Megan Fox.

The schedule:
First Round Voting: March 19-22 Over, click here for winners!
Second Round Voting: March 23-26 Over, click here for winners!
Sweet 16 Voting: March 27-29 Over, click here for winners!
Elite Eight Voting: March 29-31 Over, click here for winners!
Final Four Voting: April 1-3
Championship Voting: April 4-6
The champion will be announced on April 7th!

Check out the full bracket of all 64 Female Celebs here, you can even print it out and keep track of winners & losers!

See the men's bracket here!