The Mummy star began dating The Wrestler director in 2002 and the pair became engaged in 2005. The couple, who share a four-year-old son, Henry, separated "some months" ago, according to the stars' representative.
A spokesperson tells TMZ.com, "Rachel Weisz and Darren Aronofsky have been separated for some months. They remain close friends and are committed to raising their son together in NYC (New York City)."
They are reportedly seeking joint custody of their son.