Hotshot plastic surgeons Dr. Sean McNamara (Dylan Walsh) and Dr. Christian Troy (Julian McMahon) experience full-blown midlife crises as they confront career, family and romance problems over six seasons of the groundbreaking series "Nip/Tuck."

Set first in South Miami Beach and later moving to L.A., these cutting-edge stories range from funny to suspenseful to uncommonly powerful. Surgeries are graphically bold. Sexuality is rampant.

Guest stars who go under the knife include Rosie O’Donnell, Joan Rivers, Kathleen Turner and Larry Hagman, among others.

From "Glee" co-creator Ryan Murphy, "Nip/Tuck" is a prescription for entertainment unlike anything you’ve ever seen.

Check out more photos of "Nip/Tuck" here!