What keeps a family together? Nick Cassavetes, the director of The Notebook and John Q, again demonstrates his sure hand with tales of deep human emotion in the inspiring film My Sister's Keeper about a loving family challenged - and united - by a child's illness.

Cameron Diaz, Abigail Breslin, Alec Baldwin and others in an exceptional cast bring sensitivity to the story of 11-year-old Anna Fitzgerald, conceived to be a donor for her leukemia-stricken sister, and who finally demands the right to control her own body.

This act of free will may tear the Fitzgeralds apart. Or it may be the first step to a triumphant realization of devotion, dignity and what it means to be a family.

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Image © Warner Bros. Entertainment Inc.