Zooey Deschanel, star of the romantic comedy "(500) Days of Summer" and sister of Bones' Emily Deschanel, will guest-star in "The Goop on the Girl," a special holiday-themed episode of "Bones" airing Thursday, Dec. 10 (8:00-9:00 PM ET/PT) on FOX.

In this first-ever on-screen pairing of the Deschanel sisters, Zooey Deschanel plays Margaret Whitesell, a distant relative of Dr. Temperance Brennan (Emily Deschanel). When Brennan's father, Max Keenan (guest star Ryan O'Neal), makes contact with Margaret, he invites her to spend Christmas with him and his daughter. Meanwhile, Brennan and Booth (David Boreanaz) investigate the death of a man dressed as Santa Claus who was blown up after a botched bank robbery.

The milestone 100th episode of "Bones," directed by Boreanaz, will air in spring 2010.

See more photos of Zooey Deschanel here!

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(This news article provided by World Entertainment News Network)