Oprah Winfrey will guest-star in one episode of NBC's critically acclaimed, Emmy Award-winning comedy "30 Rock" in the season's second episode airing on November 6 (Thursday, 9:30-10 p.m. ET). Winfrey filmed her role at "30 Rock's" Silvercup studios in New York City on Saturday.

"Oprah Winfrey's presence on '30 Rock' makes this episode a television event," said Teri Weinberg, Executive Vice President, NBC Entertainment. "She is a true legend in her own time, and in this comedy's tradition, it provides the perfect showcase for stars of her renowned status. We are all thrilled."

"Oprah is very funny in the episode and we are beyond grateful to have her. Also, I would like to announce that we are officially best friends," Tina Fey, creator, executive producer and star of "30 Rock."