"America's Most Wanted: America Fights Back" teams with actress Pauley Perrette ("NCIS") on the season premiere Saturday, Sept. 8 (9:00-10:00 PM ET/PT) on FOX. As AMW kicks off its 21st season, Perrette joins forces with host John Walsh to help find the killers of two young girls.

Like millions of other TV viewers, Perrette is an avid watcher of FOX's crime-busting series. "I'm the biggest AMW fan, and always have been," she says. "I talk about it all the time." But an AMW broadcast this past spring prompted her to do more than talk. The show included stories about the unsolved murders of two young girls, Raven Jeffries in Detroit and Shannon Paulk in Prattville, AL. Perrette has family in Prattville, and her boyfriend is from Detroit. She saw it as a sign. "I couldn't stop thinking about those two little girls and also how strange it was that it was Detroit and Prattville, his family, my family. It could be my niece, my family, it could have been anybody. It could have been anybody's kid."

After Perrette donated $10,000 to the reward fund for each girl's case, AMW producers invited her to join their investigation. In the episode, Perrette travels to the crime scenes and other key locations in Alabama and Detroit, meets with detectives and learns more about Raven and Shannon's tragic deaths. She's calling on her fellow AMW viewers to do their part by sending tips to the show's confidential hotline, 1-800-CRIME-TV.