TBS's new original comedy series "My Boys" is set to welcome four special guest stars on upcoming episodes: Laurie Metcalf and Johnny Galecki, both of whom co-starred in the long-running comedy hit Roseanne; Neil Flynn, who plays the notorious janitor on Scrubs; and Colin Ferguson, who stars in the new series Eureka.

Galecki will first appear in the episode "Clubhouse Poison," set to air Tuesday, Dec. 12, and will be joined by Ferguson in the episode "One for the Team," airing Tuesday, Dec. 26. Metcalf, who had to split her time between the "My Boys" and Desperate Housewives sets during filming, and Flynn will both appear in the episode "When Heroes Fall from Grace," airing Tuesday, Jan. 2. Legendary Chicago Cubs stadium Wrigley Field and Jeannie Noth Gaffigan, Jim Gaffigan's real life wife, also make special appearances on Jan. 16 when the cast heads to Chicago for the season finale.

"My Boys," which airs on TBS Tuesdays at 10 p.m. (ET/PT), stars Jordana Spiro as PJ, an unabashed, sports-loving girl whose love life can sometimes be a challenge given that most of her friends are guys. The series co-stars Jim Gaffigan, Kyle Howard, Reid Scott, Michael Bunin , Jamie Kaler and Kellee Stewart.