3 Lbs, a new drama about a team of top New York City neurosurgeons who explore the brain -- the core of intelligence, the center of emotion and spirit and the last great medical frontier -- premieres Tuesday, Nov. 14 (10:00-11:00 p.m., ET/PT) on CBS.

“3 Lbs” stars Stanley Tucci as Doug Hanson, a brilliant neurosurgeon, with a sharp wit, who compares the workings of the brain to wires in a box. On the other hand, his thoughtful highly skilled protégé, Dr. Jonathan Seger (Mark Feuerstein), who honors the mysteries of the mind, and feels that in order to operate on someone's brain, he needs to know a little bit about the person first. While Hanson prefers to focus on the intricacies inside peoples' craniums instead of the people themselves, Seger uses his charm, instinct and intuition to balance the emotional and psychological needs of his patients.

These doctors have opposing points of view on how to treat their patients. However, this doesn't get in the way of their shared obsessions about the brain, and their growing, sometimes secret mutual respect for each other's talents and approaches which includes a healthy dose of humor that is also needed for these jobs.

A part of this gifted medical team is Dr. Adrianne Holland, a coy calculating neurologist. Armando Riesco also stars.