It must be a difficult day for Tom Cruise to celebrate his 50th birthday. Less than a week ago his wife Katie Holmes filed for divorce. Cruise has been married three times (also to Mimi Rogers and Nicole Kidman) and was reportedly blindsided by Holmes' action.

The actress has asked for full custody of their 6-year-old daughter Suri, reportedly to keep the child away from the Church of Scientology. Cruise became involved in the religion in 1990 and is their most high-profile member.

Professionally, things have also been difficult for Cruise recently. His latest film, "Rock Of Ages," was the actor's worst opening weekend ever. No film featuring the actor has made less than "Rock of Age's" $15 million with a wide release.

However, last year's "Mission: Impossible - Ghost Protocol" grossed over $209 million domestically.

Cruise stars in the upcoming film "Jack Reacher" (Dec. 21, 2012) about a homicide investigator. He has also agreed to film a fifth installment of the "Mission: Impossible" franchise and has been tapped to play vampire hunter Van Helsing.

We have to wonder if his personal life is intervening with his professional one. The actor is currently in Reykjavik, Iceland, shooting sci-fi movie "Oblivion" about a soldier who goes to a distant planet to destroy the remains of an alien race.

For an actor whose work has spanned over 30 years (he made his big-screen debut in the 1981 teenage romance "Endless Love"), Cruise has had a prolific career. Will this latest personal hiccup cause more problems for him in Hollywood?

In 2005, he came under fire for jumping on Oprah Winfrey's couch, declaring his love for Holmes. Bad press erupted following the incident, especially due to his links to Scientology and his bizarre rant against actress Brooke Shields' decision to take prescription drugs to battle her post-natal depression. They starred together in his first film.

Slideshow: Tom Cruise On The Big Screen