Mayim Bialik, “The Big Bang Theory” 

Sometimes the stars align to fatefully design a perfect role for an actor.  For “Blossom” star and real-life neuroscientist and author, the fated role was on “The Big Bang Theory” as Sheldon Cooper’s (Jim Parsons) socially awkward girlfriend, Amy Farrah Fowler.  Upon joining the show in its third season, Bialik infused the geek-friendly sitcom with an effervescent and female energy it needed. Two seasons later, Bialik's Amy Farrah Fowler is still a gawky, harp-playing, affection-starved genius who can hold her with double Emmy-winner Jim Parsons and the rest of stellar Big Bang cast.  Brava, Dr. Bialik.