The media mogul grills the family on a number of topics, from Kim's infamous sex tape and 72-hour marriage to Kris's management of the family's business affairs.
Oprah, who had never met the family or even watched the show before, posted some thoughts on the interview to her Facebook page on Thursday.
"I genuinely wanted to know why they have become a cultural phenomenon? Why do so many people love to watch their every move and why do so many others love to hate them. Are they completely ego centered? Are they really "famous for being famous" or is there something more?" She writes.
Without giving anything away Oprah tells that got all the answers she was looking for and more; and that Scott, Lamar and Khloe, and Kim were the ones who surprised her the most.
And as far as that brief marriage Kim had to NBA player Kris Humphries goes - Oprah says, "Why did she leave after 72 days? Her answer leveled me."
"It was such a surreal experience sitting down with Oprah," Kim says in a post on her official site. "it was an unforgettable experience for the entire family!"