Lori Loughlin - Who was the hottest cast member on Full House? Ok, John Stamos. But who was the hottest female cast member on Full House? That honor goes to Lori Loughlin. Back then, she was a cute girlfriend/wife/mother type who somehow had no problem moving her family into Bob Saget's attic. Today, she exudes success and maturity, and her sex appeal has actually gotten stronger with time.