The Avengers should have little trouble breaking Avatar's second weekend record, thanks in part to great reviews and word of mouth. Avatar took in just above $75 million its second weekend and pundits suggest The Avengers may break the $100 million mark.

The Avengers face no contenders for the top spot; while Johnny Depp's Dark Shadows should bring in a good haul, Box Office Mojo suggests it will "only" make $33 million.

If The Avengers beats Avatar's second weekend mark, it could be a sign that Disney's film might contend for the top domestic spot of all-time. James Cameron's sci-fi adventure, bolstered by a second theater run and 3D sales, earned $760 million domestic and $1.6 billion worldwide.