Seth Rogen and Zac Efron's comedy "Neighbors" easily overtook the competition at the weekend box office, including "The Amazing Spider-Man 2," with $51 million in ticket sales.

The film centers a couple with a new baby who discover their new neighbors are a group of fraternity boys. Both sides engage in sabotage and one-upmanship, launching an all-out war against one another.

Expected to hold on to its box office reign, "Spider-Man 2" came in at number two at the box office, making $37.1 million during its second week of release.

"The Other Woman," starring Cameron Diaz, Leslie Mann and Kate Upton, came in third with $9.6 million. Rounding out the top five were religious drama "Heaven is Real" ($7 million) and "Captain America: The Winter Soldier" ($5.6 million).