Macklemore & Ryan Lewis's latest single, "Can't Hold Us," has set a new Billboard Hot 100 chart record.

The single, which features Ray Dalton, is the second track from the duo to hit number-one, making them the only duo in history to top the chart with its first two singles.

The rappers spent six nonconsecutive weeks at the top of the charts with "Thrift Shop" (featuring Wanz) earlier this year, and have ousted P!nk's "Just Give Me A Reason" from the top spot.

The duo's third single, "Same Love," is currently at Number 83.

The top ten is rounded out with Justin Timberlake's "Mirrors," Rihanna's "Stay," Bruno Mars' "When I Was Your Man," Macklemore & Lewis's "Thrift Shop," Icona Pop's "I Love It," Imagine Dragons's "Radioactive," Florida Georgia Line's "Cruise," and Pitbull's "Feel This Moment."