Emmy Award winner Julianna Margulies has been cast as the lead actress in Sci Fi Channel's 2006 limited series event, “The Lost Room.” Margulies will star opposite Peter Krause and joins Roger Bart and Elle Fanning in the all-star ensemble.

Margulies will play Jennifer, a mysterious woman who contacts Detective Joe Miller (Krause) claiming her brother was killed for a seemingly innocuous motel room key, one that actually has the power to unlock a door into a room full of ordinary objects possessing unimaginable power.

When Detective Miller comes into possession of the key, Jennifer tries to warn him of the inherent danger of The Lost Room and the objects within. But when Miller's own daughter (Fanning) vanishes into the room, he must form an uneasy alliance with Jennifer, who opens his eyes to a world of secret cabals who will stop at nothing to secure the key.