Twelve years after her first short-lived chat show ended, the actress returned to the small screen to launch "The Queen Latifah Show" with a little help from her A-list friends.
Latifah told the audience: "Thank you so much for being with me today, and really throughout my whole career. Everything that I have done has led me to this moment.
"This is my chance to do all of the things that I love. I get to introduce you to amazing people who are doing extraordinary things. I get to showcase the best entertainers, and of course I get to laugh my Spanx off."
Latifah's first guest was Travolta, who discussed his career and family. Alicia Keys and Latifah suprised a California high school band teacher with a jamming session. They also renovated the school's band room and donated new instruments.
MC Lyte served as house DJ.