Host Chelsea Handler sat down with the star and mentioned how Jenny was unable to accompany Jason to the show. Jenny did, however, send an image of her large breasts - which Chelsea showed to viewers.
In response, Biggs explained: "Her breasts are very big these days. Would you like to know why? Cause I put a baby in her belly!"
He later posted on Twitter: "My wife @jennyandteets is pregnant. My sincerest apologies to Kate Middleton for stealing all of her thunder. #AmericasBaby."
The couple has a history of being outrageous. In May, they mocked a controversial Time magazine cover in which a woman was breastfeeding her 4-year-old son. They posted an image on Twitter showing the actor kneeling on a chair and suckling his wife's breast.
Jason and Jenny met while filming "My Best Friend's Girl" in 2008.