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Callum Blue

Kiele Sanchez

Lizzy Caplan

Jennifer Esposito

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In New York, four sisters try to keep their heads above water despite the demands of family and career: the eldest daughter's marriage is on the rocks; the workaholic sister is forced to slow down when she learns she's pregnant; the public relations maven is facing a major career challenge and the baby of the family has just switched her college major from pre-med to experimental dance.