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Episodes:
Emancipation
The team takes on the case of a 16-year-old who fell ill when her lungs suddenly filled with fluid. The teenager tells House and team that she is an emancipated minor supporting herself, and has, ever since her parents passed away. The team thinks it could be heart problems, but when Kutner chooses not to follow House's directions, the team finds out that the girl may not be telling them the truth. Meanwhile, Foreman asks House for permission to work on a clinical trial, and is rejected. To prove himself, Foreman takes on his own pediatric case. But when the now solo Foreman brings the child close to death, Foreman must question his ability to work without House.

The Softer Side
The team encounters a teenage boy who collapsed from severe pelvic pain after playing basketball. Tests reveal the boy has genetic mosaicism, or both male and female DNA, and the boy's parents inform House and the team that the boy is unaware of his condition. They consciously chose a gender for him when he was born and raised him accordingly, never telling him about his unique condition. However, when his condition worsens and his life is threatened, the parents wonder whether they made the right decision. Meanwhile, Cuddy and Wilson suspect something is wrong with House when he starts acting way too nicely. When they discover the shocking answer, they must face the prospect that House may be changed forever.

Unfaithful
House takes on the case of a priest who runs a homeless shelter, who sees a bleeding Jesus over his doorstep and is admitted to the ER. The team learns that the priest was involved in a molestation scandal that took away his faith. As the patient's condition worsens, however, House struggles with his own beliefs.

Big Baby
Cuddy wants to spend more time at home with her newly adopted baby, so she passes some of her responsibilities off on Cameron, including monitoring House. Cameron must play House's games, which ultimately turns into a power struggle, when he and the team take a new case. The case involves a Special Education teacher who collapses after coughing up blood during class. Meanwhile, Foreman has to make a decision, as to whether or not he should continue with Thirteen as a participant in the Huntington's drug trial.

Let Them Eat Cake
A high-profile fitness trainer collapses while shooting an infomercial. House and the team test her for exercise-induced asthma, steroid abuse or even a possible vitamin deficiency, but nothing checks out and the instructor's condition continues to worsen. The team soon finds out she had stomach reduction surgery that may be the cause of her condition but the revelation would ruin her career. Meanwhile, Thirteen starts her clinical drug trial for Huntington's disease, Kutner starts an online medical advice clinic under House's name, and Cuddy moves into House's office.

Joy To The World
The team encounters a teenager who fainted during her high school Christmas play. They find the troubled teen dealt with more than her share of bullying and, as her condition gets worse, the team works harder to uncover her mysterious illness. Foreman, still working with Thirteen, learns a valuable lesson from her. House gives a patient an unbelievable gift and keeps the team wondering who may have sent a particularly thoughtful present. Meanwhile, Cuddy gets an unexpected gift of her own.

The Social Contract
House and the team take on the case of Nick, a book editor who loses his inhibition and starts insulting co-workers at a dinner party one night before falling ill. The team realizes Nick has frontal lobe inhibition, which has caused him to lose his filter and vocalize all of his innermost thoughts, resulting in extremely insulting outbursts. As Nick's free speech lends to some amusing and insightful comments regarding the team, he must deal with the consequences of being unable to lie to his wife and everyone else important in his life. Meanwhile, House suspects Wilson and Taub are keeping something from him when he catches them both in a lie.

Lucky Thirteen
A woman with whom Thirteen had a one-night stand falls ill and has a seizure at Thirteen's apartment. Thirteen takes the woman to Princeton-Plainsboro where House and the team take her case. House can't wait to get in to Thirteen's personal life, and he and Foreman search Thirteen's apartment to find possible causes for the woman's illness. Thirteen thinks the woman's drug use caused her condition, but she finds out the patient has a long medical history. Thirteen soon finds out the patient slept with her only to get to House, and that she had been trying to get House to take her as a patient for years. Foreman confronts Thirteen's hard-partying lifestyle, warning her that her attitude is sending her life and job into a downward spiral.

Joy
A middle-aged man experiencing blackouts is admitted to Princeton-Plainsboro. With diagnoses ranging from stroke, a concussion to toxins from the consumer products he has been testing for work, House and the team soon find that the man has been experiencing sleepwalking spells. While trying to figure out what the cause of the man's illness could be, his daughter develops the same symptoms. Later, House finds out Cuddy is going to adopt. But when Cuddy notices a strange rash on the mother-to-be's arm, Cuddy brings her in for the team to take a look at. With the mother's condition getting continuously worse, Cuddy must take on the case as both a doctor and a potential mother.

Birthmarks
When House receives word that his father has passed away, he brushes off the news and dismisses the idea of going to the funeral. However, he is soon coerced into going despite his strongest protests. Back at Princeton-Plainsboro, the team encounters the case of a young Chinese woman, adopted by American parents, who collapsed while in China looking for her birth parents. With House en route to his father's funeral, he must work with the team to diagnose the woman via cell phone while on the road. The team runs through possible diagnoses and various genetic disorders, but when House's phone dies, the team must decipher what House was trying to tell them before the girl's condition deteriorates.

House Divided
The team takes on the case of a deaf 14-year-old named Seth who collapsed after he started "hearing" explosions while competing in a wrestling match. When the team tries to test him for seizures, Seth loses vision in one eye, complicating House's bunk theory of "Exploding Head Syndrome." As his condition worsens, the team has an ethical disagreement about the patient and his mother's adamant decision to forego cochlear implants to supplement his hearing. When the prospect of giving Seth the ability to hear for the first time in his life arises, House and the team are faced with a resounding decision. Meanwhile, House's lack of sleep starts to play tricks on his mind, but he finds his insomnia may be a gift instead of a burden.

Not Cancer
When several people suddenly die without warning, House and the team rush to save others that may have received transplants from the same donor five years prior. With one of two already dying and the other healthy but sure to get sick eventually, the team focuses on the original organ donor. The team sorts through the records on the deceased donor recipients to find the common thread. Meanwhile, House hires Lucas, a private investigator to dig up information about the deceased despite the team's skepticism. House auditions new best friends to replace Wilson, and soon, uses Lucas to spy on himself.

The Greater Good
The team takes on the case of a woman who fainted during a cooking class. House and the team soon realize she is a highly-renowned cancer researcher, who gave up her career to pursue personal happiness. As the patients condition worsens, Thirteen begins to suffer life-threatening reactions to the experimental Huntington's Disease clinical trial. Meanwhile, Cuddy tries to make House's life unbearable for his part in her own personal sorrow.

Painless
House and the team take on the case of a man, living with severe chronic pain, who tries to take his own life after living for years without a diagnosis or any relief from his suffering. Parallels between the patient and House's experiences with prolonged pain become apparent. When the patient attempts suicide again, the search for answers becomes more urgent. Meanwhile, Foreman and Thirteen explore their relationship as they work together on the Huntington's disease drug trial. Cuddy finds that taking care of her adopted baby leaves her little time to run the hospital and look after House at the same time.

Adverse Events
The team takes on the case of a struggling artist who has been painting crazy pictures. His perception has been distorted by his illness, and its threatening to ruin his life. The team finds out the artist has had some bad luck. Not being able to sell any art, the guy has been forced to resort to three separate drug trials in order to pay the bills. House must figure out which of the three drugs is the cause of the illness before it is too late. Meanwhile, House continues to have his private investigator dig up dirt on everyone on his team, including Taub, who is having trouble in his marriage.

Locked In
Lee awakens after a bicycle accident in New York unable to move or communicate verbally. From his unique perspective, we hear Lee's inner thoughts as House, injured in a motorcycle accident, occupies the hospital bed next to him. House takes notice of Lee as his doctor writes him off as being brain-dead and begins to arrange his organ donations. However, House confirms that Lee is not brain dead at all, but rather has "locked-in" syndrome. He is completely conscious, but unable to let anyone know. As House develops a system to communicate with Lee by having him blink once for "no" and twice for "yes," he is intrigued by the case and tries to figure out what is causing Lee's condition, much to the disdain of the presiding physician. When House gets Lee transferred to Princeton Plainsboro, the team is on the case to try to save Lee. When Lee loses his ability to blink and continues to fall ill, the team must race to find the key to unlock his condition. Meanwhile, Wilson suspects House is hiding something from him when he refuses to divulge why he was in New York when he got into his motorcycle accident.

Under my Skin
House and the team take on the case of a ballerina whose lungs collapse in the middle of a performance. When the treatment causes her skin to fall off, the dancer faces not only the prospect of never dancing again but also of dying an agonizing death. The team must use their imaginations to carefully choreograph ways to test and treat her delicate body without killing her. Meanwhile, House continues to suffer from a severe lack of sleep and is still haunted by Amber. While enlisting Wilson's help to diagnose himself he is willing to do the unthinkable to make his visions stop.

The Itch
An agoraphobic man falls ill for no apparent reason, and refuses to leave his home to get treatment. House and the team go to the man's house to figure out what might be wrong, but Cameron takes charge, as she has treated the patient before. The team figures out ways to bring the hospital to the patient's home, but Cuddy disapproves. As the patient's condition gets worse and their options for treating him at home become limited, House and the team try and trick the patient into going to the hospital for surgery without causing any further anxiety. Meanwhile, Cameron and Chase attempt to work through some rough patches in their relationship, and Wilson comes up with some analogies about House's situation.

Saviors
Cameron postpones her vacation with Chase in order to ask House to accept the case of an environmental radical who collapsed at a protest with unexplainable symptoms. Although suspicious of her motives, House agrees. Since she pushed him to take the case so emphatically, House forces Cameron to take the lead and run many of the tests on the patient. Meanwhile, House is unsure of Wilson's new healthy diet.

Dying Changes Everything
Wilson still mourns two months after the death of Amber. Needing to make a change in his life, Wilson leaves Princeton-Plainsboro and his best friend, House. Wilson is forced to decide if House is a strain on his life, while House struggles with feeling responsible for the death of his best friend's girlfriend. The team's next case involves an assistant to a high-profile executive. The team suspects that the patient's symptoms stem from being over-worked, but when her shocking medical condition worsens, Thirteen struggles to treat the patient objectively without bringing the reality of her own medical condition to the case. Meanwhile, Cuddy attempts to save the guys' relationship.

Simple Explanation
Charlotte, an older woman who has spent the last six months taking care of her husband Eddie, is rushed to Princeton Plainsboro for immediate treatment after collapsing from respiratory failure at Eddie's deathbed. With both in the hospital, the husband and wife team become a double mystery when Eddie's condition sporadically improves while Charlotte's condition deteriorating. The urgency of Charlotte's medical condition breathes new life into their romantic relationship, and their regrets of what could have been are replaced with tenderness as Charlotte informs the team she wants Eddie to have her heart should she die before him. The team is forced to make a difficult choice as both of their lives are nearing an end.

Here Kitty
House and the team take on the case of Morgan who works in a nursing home with a pet cat who only sleeps next to people if they are about to die and does so with alarmingly accuracy. When it seems the cat has predicted her own death, Morgan, convinced she is about to die, fakes a seizure in order to get to House to have him diagnose her before it's too late. House dismisses her as a nut job, but is intrigued with the claim about the cat and sets out to disprove Morgan's theory. When she falls seriously ill, he and the team are forced to get to the bottom of her mysterious illness as well as the mystery of the cat with the kiss-of-death. Meanwhile, Taub struggles with his finances and reconnects with an old high school friend at the clinic whose business successes present Taub with an entrepreneurial opportunity he had not previously considered.

Both Sides Now
House and the team are intrigued by Scott, a man whose left brain and right brain operate independently, leaving him with two distinct personalities and no control over some of his actions. As the two sides of Scott's brain struggle for dominance, his warring personalities make it increasingly difficult for the team to figure out what is causing the unique problem. The team is forced to use some unusual methods to get him to cooperate with their necessary testing. Meanwhile, when House refuses to make an appearance in the clinic, Cuddy takes an unconventional approach to force House to make up the time with a particular patient.

Last Resort
A gun-toting man from the ER waiting room takes House, Thirteen and a few patients from the waiting room hostage in Cuddy's office. The man claims to have a long undiagnosed illness, and demands attention from the best doctor in the hospital. With a room full of patients, House uses them as guinea pigs to assure the gunman that the medications he plans to use are legitimate. The team and Cuddy communicate with House over the phone, to run tests and offer diagnoses. When one hostage is shot, Thirteen puts her own health on the line, as she simultaneously receives the treatments the hostage is getting. House is determined to diagnose the hostage-taker, but the SWAT team's plan to put an end to the standoff, may put the entire room at risk.





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