The Chris Isaak Show Cast and Crew
| Cast |
 Mark Acheson - (Technician) |
| Grahame Andrews - (Minister) |
 Adam Arkin - (Jimmy Vane) |
| Kristian Ayre - (Brian) |
 Bai Ling - (Herself) |
| Jianna Ballard - (Girl) |
| Scott Barratt - (Faux Kenny) |
| Bif Naked - (Herself) |
| Paul Bittante - (Officer No 1) |
| Rita Bozi - (Marissa) |
| Junior Brown - (Himself) |
| Michael R Coleman - (Dennis) |
 Shawn Colvin - (Himself) |
 Mia Cottet |
| Mitch Davies - (Male Cop) |
| John Destry - (Tom) |
| Holly Dignard - (Saleswoman No 1) |
| Bill Dow - (Marty Weiss) |
| Jasmin Dring - (Asian Woman) |
 Minnie Driver - (Herself) |
 Kevin Eubanks - (Himself) |
| Barbara Fixx - (Meg) |
| Vincent Flueck - (Howard) |
 Brad Garrett - (Himself) |
| Brian George |
 Peri Gilpin - (Herself) |
| Haley Ingram - (Irene's Daughter) |
| Benita Ha - (Saleswoman No 2) |
| Zahf Hajee - (Harian) |
| Heather Hanson - (Monique) |
| Rebecca Harker - (Assistant) |
 Adam J. Harrington - (Father Ken McCurdy) |
| Dean Hinchey - (Faux Roly) |
| Allison Hossack |
| Mark Houghton - (Clay Choper) |
| Woody Jeffreys - (Stone) |
| Linnea Johnson - (Carol) |
| Willow Johnson - (Young Woman) |
| Andrew Jonston - (Mr Bloom) |
| Irene Karas - (Judy) |
| Greg Kean - (Lou) |
| Andrew Laurenson - (Scott) |
 Jay Leno - (Himself) |
| Lisa Loeb - (Herself) |
| Chris Logan - (Transvestite Cocktail Waitress) |
| Santo Lombardo - (Kitchen Worker) |
| Tony Massil - (Young Man) |
| Kevin McNulty - (Merrill) |
 Gabrielle Miller - (Bonnie) |
| Claudette Mink - (Maria) |
| Paul Moniz De Sa - (Pear Shaped Man) |
| Eliza Murbach - (Kim) |
| Vince Neil - (Himself) |
| Donna Newman - (Michelle) |
 Stevie Nicks - (Herself) |
| Rebecca Nygard - (Jodie) |
| Julie Patzwald - (Monica) |
| Tammy Pentecost - (Sheila) |
| Taylor Anne Reid - (Chloe) |
| Johnny Reno - (Ordell) |
 Gloria Reuben - (Herself) |
 Caroline Rhea - (Herself) |
 Ryan Robbins - (Deke) |
| Emilio Salituro - (Chef) |
| Jacqueline Samuda - (Nedra) |
| Alvin Sanders - (Jo Jo) |
| Charles Siegel - (Tricia Miller) |
| Sarah Strange |
 Victoria Tennant - (Irene) |
 Jennifer Tilly - (Herself) |
| Zoran Vukelic - (Jean-Baptiste) |
| Joe Walsh - (Himself) |
| Brian Whyte - (Himself) |
| Peter Wingfield - (Denver Lane) |
| Robert Wisden - (Dr Morse) |
| Dweezil Zappa |
| Patricia Zentilli - (Lauren Davis) |
| John Milton Branton - (Base Dealer) |
| Art Kitching - (Minister) |
| Writer |
| Joe Bosso |
| William Lucas Walker |
| David Rothenberg |
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