- O'Day, Aubrey
- O'Donis, Colby
- O'Donnell, Daniel
- O'Jays, The
- O'Neal, Jamie
- O'Reagan, Tim
- O'Riordan, Dolores
- O'Ryan
- O, Karen
- O-Town
- O.A.R.
- O. Children
- Oakenfold, Paul
- Oakley Hall
- Oak Ridge Boys, The
- Oasis
- Oberst, Conor
- Obituary
- Oblivion Sun
- Ocasek, Ric
- Ocean, Billy
- Ocean, Frank
- Oceansize
- Ocean Colour Scene
- OConnor, Sinead
- Octopus Project, The
- Odd Future
- Office
- Office, The
- Offspring
- Of Montreal
- Ohmega Watts
- Oh Land
- Oingo Boingo
- Okkervil River
- OK Go
- Olatunji, Babatunde
- Oldfield, Mike
- Old & In the Way
- Old 97's
- Old Crow Medicine Show
- Old Man's Child
- Oleander
- Olivia
- Ollabelle
- Olsson, P.J.
- Olstead, Renee
- Ol Dirty Bastard
- Omar, Don
- Omarion
- Omnisoul
- Once Nothing
- OneRepublic
- One AM Radio, The
- One Be Lo
- One Block Radius
- One Call
- One Chance
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- One Day as a Lion
- One Direction
- One Fine Day
- One Nine Hundred
- Ono, Yoko
- Onyx
- On Broken Wings
- OOIOO
- Oomph!
- Operation Ivy
- Operator
- Operator Please
- Opeth
- Orbison, Roy
- Orbital
- Oreskaband
- Orfeh
- Orgy
- Orianthi
- Orishas, Los
- Orleans
- Orrico, Stacie
- Orson
- Ortega, Fernando
- Ortega, Jeannie
- Ortega, Lindi
- Orton, Beth
- Osborne, Jeffrey
- Osborne, Joan
- Osbourne, Johnny
- Osbourne, Kelly
- Osbourne, Ozzy
- Osmond, Donny
- Osmonds, The
- Os Mutantes
- Otep
- Otis, Shuggie
- Otsuka, Ai
- Otto, James
- Ours
- Our Lady Peace
- Our Last Night
- Outen, Savannah
- Outfield, The
- Outfield, The
- Outkast
- Overkill
- Over It
- Over the Rhine
- Owen, Jake
- Owen, Judith
- Owen, Randy
- Owens, Buck
- Owl City
- Oysterhead
- Ozomatli
- Ozric Tentacles
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