A patchwork of stories about various factions of the drug trade, including dealers, abusers and the law enforcement officials who pursue them. Mexican policeman Javier Rodriguez works on and around the border with his close friend and fellow policeman Manolo Sanchez, under Mexico's number one crime fighter, General Salazar. Confronted with temptations of power and money, Javier resists them but finds himself--and Manolo--caught in a web of corruption that leads to an untenable situation. Back in the U.S., Ohio State Supreme Court Justice Robert Wakefield is named by the president as the new antidrug czar. Collecting information, the uncompromising and conservative Wakefield prepares to supervise the country's task forces and partner them with Mexico's. But, at home, he and his wife Barbara must deal with their increasingly drug-addicted teenage daughter Caroline.
In San Diego, undercover DEA agents Montel Gordon and Ray Castro work overtime to help the U.S. government build its case against the infamous Obregon drug cartel. Their bust of midlevel drug trafficker Eduardo Ruiz pays off when their new prisoner cuts a deal to testify against wealthy drug baron Carlos Ayala, who lives in the upscale suburbs. Carlos is arrested, shocking his unknowing and pregnant wife Helena. Helena and her son are quickly threatened by her husband's associates and tailed by the DEA agents. Enlisting the aid of attorney Arnie Metzger. Helena vows to get Carlos out of jail and keep her children safe--even if it means taking over her husband's business.