Tenacious D in the Pick of Destiny Cast and Crew
 Jack Black - (JB) |
 Kyle Gass - (KG) |
 JR Reed - (Lee) |
| Troy Gentile - (Lil' JB) |
 Ronnie James Dio - (Dio) |
 Paul F. Tompkins - (Open Mic Host) |
| Ned Bellamy - (Security Guard) |
 Fred Armisen - (Security Guard) |
| Kirk Ward - (Car Chasing Cop) |
| Kirk Ward - (Gang Leader) |
 Amy Poehler - (Truck Stop Waitress) |
 Tim Robbins - (The Stranger) |
 Dave Grohl - (Satan) |
 Ben Stiller - (Guitar Centre Guy) |
| Lara Everly - (Girl) |
| Brittany Eldridge - (Girl) |
| Melissa-Anne Davenport - (Girl) |
| John Ennis - (Gang Member) |
| V.J. Foster - (Gang Member) |
| Jay Johnston - (Gang Member) |
| Christopher 'C-Minus' Rivas - (DJ) |
 Colin Hanks - (Drunk Frat Dude) |
| Stephanie Erb - (Al's Bar Waitress) |
 Amy Adams - (Gorgeous Woman) |
| Milos Milicevic - (Tattooed Biker) |
| Molly Bryant - (Ecstatic Woman) |
| Michael Rivkin - (Poopy Guy) |
| Neil Hamburger - (Stand Up Comic) |
| Patrick Walsh - (Exploding Head Guy) |
| Bevin Kaye - (Fainting Woman) |
| Evie Peck - (KG's Mother) |
| Mason Knight - (Young KG) |
| Erik Walker - (Bully) |
| Dean Marchiano - (Bully) |
| Cynthia Ettinger - (Betty Black) |
| Andrew Caldwell - (Billy Black) |
| Laura Milligan - (Tarot Card Reader) |
 Meat Loaf - (JB's Father [Uncredited]) |
 John C. Reilly - (Sasquatch [Uncredited]) |
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