Osmosis Jones Cast and Crew
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 Bill Murray - (Frank) |
 Molly Shannon - (Mrs. Boyd) |
 Chris Elliott - (Bob) |
| Elena Franklin - (Shane) |
 Chris Rock - (Osmosis Jones) |
 David Hyde Pierce - (Drix) |
 Laurence Fishburne - (Thrax) |
| Brandy Norwood - (Leah) |
 William Shatner - (The Mayor) |
| Danny Murphy - (Zookeeper Superintendent) |
 Kid Rock - (Kidney Rock) |
 Ron Howard - (Tom Colonic) |
| Joe C |
| The O'Day Family - (Zoo Visitors & Staff) |
| Maura O'Brien - (Emergency Room Nurse) |
| Marlene Malone - (Zoo Visitors & Staff) |
| Barbara O'Connor - (Zoo Visitors & Staff) |
| Grady O'Connor - (Zoo Visitors & Staff) |
| Danny Mann |
| The Oberholtzer Family - (Science Fair Family) |
| Emily O'Donnell - (Science Fair Contestant) |
| Ken Olson |
| Emily O'Day - (Volcano Gal) |
| Colleen O'Donnell - (Docky's Clamshack) |
| Diana O'Donnell - (Science Fair Contestant) |
| The Madigan Family - (Science Fair Family) |
| Sherry Lynn |
| Bruce McIntyre - (Pea Soup Staff) |
| Ruth Meyer - (Zoo Visitors & Staff) |
| The Mone Family - (Docky's Clamshack) |
| Brian Mone - (Police Officer) |
| "Stuttering" John Melendez |
| Mickie T. McGowan |
| Hector Mercado |
| Bob O'Brien - (Zoo Visitors & Staff) |
| Mandy Marsh - (Zoo Visitors & Staff) |
| Jillian Nicewicz - (Docky's Clamshack) |
| Jo Ann Ninewicz - (Docky's Clamshack) |
| The Murphy Family - (Zoo Visitors & Staff) |
| Joe Murphy - (Bikini Gang) |
| The Neville Family - (Zoo Visitors & Staff) |
| Jack McCullough - (Zookeeper) |
| Anne Lockhart |
| Nikki Tyler-Flynn - (Nurse #2) |
| Paul Tuerpé |
 Uncle Kracker |
| The Urann Family - (Science Fair Family) |
| The Sumner Family - (Science Fair Family) |
| Keri Tombazian |
| Steve Susskind |
| The Tom Beauchene Family - (Zoo Visitors & Staff) |
| The Sullivan Family - (Zoo Visitors & Staff) |
| Morgan Wentzell - (Zoo Visitors & Staff) |
| Jacqueline Wentzell - (Zoo Visitors & Staff) |
| The Winans Family - (Science Fair Family) |
 Robert Wisdom |
| Chandler Vuillemier - (Volcano Gal) |
| The Vuilleumier Family - (Science Fair Family) |
| Kathy Wege - (Volcano Lady) |
| Bill Wade - (Pea Soup Staff) |
| Warwick West Side All-Stars - (Zoo Visitors & Staff) |
| Mattie Ostiguy - (Emergency Room Nurse) |
| Jesse Peter - (Laughing Boy) |
| The Perry Family - (Zoo Visitors & Staff) |
| The Peterson Family - (Science Fair Family) |
| Chris Phillips |
| Lynne Redding |
| Paul Pape |
| Zak Penn - (Emergency Room Doctor #3) |
| Marilyn Pasekoff |
| The Pelham Family - (Zoo Visitors & Staff) |
| Amy Suhay - (Bikini Gang) |
| Dick Silva - (Science Fair Contestant) |
| The Shields Family - (Zoo Visitors & Staff) |
| Herschel Sparber |
| Doug Stone |
| The Reske Family - (Zoo Visitors & Staff) |
| The Ripley Family - (Science Fair Family) |
| Dick Rubin - (Bikini Gang) |
| Al Rodrigo |
| The Roy Family - (Zoo Visitors & Staff) |
| The Woodgate Family - (Zoo Visitors & Staff) |
| Bo Cleary - (Pea Soup Staff) |
| Paul Christie |
| Diane Conrad - (Zoo Visitors & Staff) |
| Judy Conrad - (Zoo Visitors & Staff) |
| Brianna Cabral - (Volcano Gal) |
| The Charpentier Family - (Docky's Clamshack) |
| Michael Carven |
| The Cavallo Family - (Science Fair Family) |
| Nancy Byers - (Pea Soup Supervisor) |
| Buzz Dunn - (Science Fair Contestant) |
| Docky - (Bikini Gang) |
| Laura Dunn - (Science Fair Contestant) |
| Willy Dunn - (Oyster Boy) |
 Eddie Barth |
| Allison Barbieri - (Zoo Visitors & Staff) |
| Maryjane Foy - (Docky's Clamshack) |
| Allison Kacmar - (Science Fair Contestant) |
| Art Kimbro |
| The Buechs Family - (Science Fair Family) |
| Catherine Dunphy - (Volcano Gal) |
| Jimmy Heres - (Zoo Visitors & Staff) |
| The Bill Beauchene Family - (Science Fair Family) |
| The Coughlan Family - (Science Fair Family) |
| Krista-Jean Froand - (Science Fair Contestant) |
| Rachael Kasner - (Bikini Gang) |
| Bob Fennessey - (Zoo Visitors & Staff) |
| Antonio Fargas |
| Sean Fitzgerald - (Police Officer) |
| Nicole Brathwaite - (Volcano Gal) |
| Janis Dardaris |
| Jackie Gonneau |
| George Kouri - (Bikini Gang) |
| Jackie Flynn - (School Janitor) |
| Elizabeth Jordan - (Nurse #3) |
| Donald Fullilove |
| Helen Britten - (Zoo Visitors & Staff) |
| Sally Ann Brooks |
| Patricia Guiggey - (Bikini Gang) |
| The Krupa Family - (Docky's Clamshack) |
| Zen Gesner - (Emergency Room Doctor #1) |
| Keith Anthony |
| Kevin Flynn - (Docky's Clamshack Waiter) |
| Thomas Jordan - (Zoo Visitors & Staff) |
| Rif Hutton |
 Carlos Alazraqui |
| The Brumley Family - (Science Fair Family) |
| The Dunphy Family - (Zoo Visitors & Staff) |
| Jamie Heres - (Zoo Visitors & Staff) |
| Rodger Bumpass |
| Tom Barbieri - (Zoo Visitors & Staff) |
| Grace Costa - (Emergency Room Nurse) |
| Kathryn Frick - (Nurse #1) |
| Christina Kacmar - (Science Fair Contestant) |
| Joyce Kurtz |
| Steve Berens - (Stunts) |
| Anna Byers - (Bus Girl #2) |
| Stefanie Eulinberg |
| Heidi Hetzel - (Bikini Gang) |
| Eddie Frierson |
| Jimmie Bones |
| The Curran Family - (Zoo Visitors & Staff) |
| Sean Gildea - (Dreamy Photographer) |
| The Kouri Family - (Zoo Visitors & Staff) |
| The Ferguson Family - (Zoo Visitors & Staff) |
| Erica Johnson - (Zoo Visitors & Staff) |
| John Britten - (Zoo Visitors & Staff) |
| Wendy Dillon |
| Shannon Gregory |
| Jason Krause |
| Sidney Bartholomew Jr. - (Zoo Visitors & Staff) |
| Marc Hyman - (Emergency Room Doctor #2) |
| Kena Flynn - (Science Fair Contestant) |
| Kelsey Jordan - (Bus Girl #1) |
| Richard S. Horvitz |
| The Brown Family - (Zoo Visitors & Staff) |
| The Hallowell Family - (Zoo Visitors & Staff) |
 Ben Stein - (The Doctor) |
 Joel Silver - (The Chief) |
| John-Eliot Jordan - (Pea Soup Manager) |
 Jonathan Adams |
Production Credits:
Piet Kroon (Animation Director)
Tom Sito (Animation Director)
Mark Irwin (Cinematographer)
Randy Edelman (Composer (Music Score))
Bobby Farrelly (Director)
Peter Farrelly (Director)
Bradley Thomas (Producer)
Dennis Edwards (Producer)
Bobby Farrelly (Producer)
Peter Farrelly (Producer)
Zak Penn (Producer)
Sidney Bartholomew Jr. (Production Designer)
Steve Pilcher (Production Designer)
Marc Hyman (Screenwriter)
Harry Sabin (Supervising Animator)
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