My Sister's Keeper Cast and Crew
| Cast |
 Cameron Diaz - (Sara Fitzgerald) |
 Abigail Breslin - (Anna Fitzgerald) |
 Alec Baldwin - (Campbell Alexander) |
 Jason Patric - (Brian Fitzgerald) |
 Sofia Vassilieva - (Kate Fitzgerald) |
 Joan Cusack - (Judge De Salvo) |
 Thomas Dekker - (Taylor Ambrose) |
 Nicole Lenz - (Gloria) |
 Heather Wahlquist - (Aunt Kelly) |
 Evan Ellingson - (Jesse Fitzgerald) |
| Brennan Bailey - (Jesse age 10) |
| Rico Simonini - (Process Server) |
| Olivia Fine - (Anna age 6) |
| Annie Wood - (Uncle Tommy's Wife) |
| Kaiulani Kimbrell - (Backup Prom Singer) |
| Walter Raney - (Pawn Shop Proprietor) |
| Paul Christopher Butler - (Jesse age 3) |
| Olivia Hancock - (Kate age 2) |
| Jeffrey Markle - (Dr Wayne) |
 Emily Deschanel - (Dr Farquad) |
| John De Rosa - (EMT) |
| Marcos De La Cruz - (EMT) |
| Noni Tulk-Perna - (Ellen) |
| Matt Barry - (Uncle Tommy) |
| Mark Johnson - (Uncle Pervis) |
| Chris Kinkade - (Dr Nguyen) |
| David Thornton - (Dr Chance) |
| E. G. Daily - (Nurse Susan) |
| Frank Cassavetes - (Gus) |
| David Bortolucci - (Harry) |
| Andrew Schaff - (Nurse Stephen) |
| Andrew Shack - (Lawyer for Previous Case) |
| Angel Garcia - (Gangbanger's Mom) |
| Frank Peluso - (Bailiff #2) |
| Daniel Guzman - (Gangbanger's Lawyer) |
| Paul Olguin - (Gangbanger) |
| Mimi Fletcher - (De Salvo's Secretary) |
 Lin Shaye - (Nurse Adele) |
| Eric Cueto - (Street Hustler) |
| Lexi Ryan - (Street Hustler) |
| Nina Barry - (Miss Swearingen) |
| Ellia English - (Nurse Alice) |
| Mary Jo Deschanel - (Saleswoman) |
| Jonah Johnson - (Lead Prom Singer) |
| Rob Giles - (Prom Guitarist) |
| Dylan Showalter - (Prom Bass Player) |
| Jarred Tibbetts - (Prom Drummer) |
| Precious Hanley - (Mandy) |
| Michael Chow - (Dr Chow) |
| Jon Moonves - (Percy Smith) |
| Director |
 Nick Cassavetes |
| Producer |
| Mark S. Kaufman |
| Diana Pokorny |
 Stephen Furst |
| Mendel Tropper |
| Toby Emmerich |
| Merideth Finn |
| Scott Goldman |
| Mark Johnson |
| Chuck Pacheco |
| Hillary Sherman |
| Steve Posen |
| Writer |
| Jeremy Leven |
| Nick Cassavetes |
| Jodi Picoult |
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