- O'Brian, Hugh
- O'Brien, Conan
- O'Brien, Dylan
- O'Brien, Edmond
- O'Brien, Emily
- O'Brien, Pat
- O'Brien, Richard
- O'Brien, Soledad
- O'Byrne, Brian F.
- O'Connell, Arthur
- O'Connell, Charlie
- O'Connell, Jerry
- O'Connor, Caitlin
- O'Connor, Carroll
- O'Connor, Donald
- O'Connor, Erin
- O'Connor, Frances
- O'Connor, Gavin
- O'Connor, Kevin J.
- O'Connor, Renee
- O'Dell, Nancy
- O'Donnell, Chris
- O'Donnell, Keir
- O'Donnell, Rosie
- O'Donoghue, Colin
- O'Dowd, Chris
- O'Halloran, Brian
- O'Halloran, Jack
- O'Hanlon, Ardal
- O'Hara, Catherine
- O'Hara, David
- O'Hara, George
- O'Hara, Kelli
- O'Hara, Maureen
- O'Hare, Denis
- O'Hare, Michael
- O'Heir, Jim
- O'Hurley, John
- O'Keefe, Dennis
- O'Keefe, Jodi Lyn
- O'Keefe, Michael
- O'Kelley, Tricia
- O'Leary, Matt
- O'Loughlin, Alex
- O'Malley, Mike
- O'Mara, Jason
- O'Neal, Patrice
- O'Neal, Ryan
- O'Neal, Shaquille
- O'Neal, Tatum
- O'Neill, Con
- O'Neill, Ed
- O'Neill, Jennifer
- O'Quinn, Terry
- O'Regan, James
- O'Reilly, Ahna
- O'Reilly, Bill
- O'Reilly, Erin
- O'Reilly, Robert
- O'Shea, Milo
- O'Toole, Annette
- O'Toole, Peter
- Oakley, Annie
- Oates, Joyce Carol
- Oates, Warren
- Obama, Barack
- Obama, Michelle
- Oberoi, Vivek
- Oberst Jr., Bill
- Obradors, Jacqueline
- OBrien, Margaret
- OBrien, Mariah
- Ochoa, Ryan
- Ochocinco, Chad
- OConnor, Frances
- OConnor, Glynnis
- OConnor, Renee
- Oda, Akane
- Odell, Jackson
- Odenkirk, Bob
- Odessa, Devon
- Odom, Darcie
- Odom, Erik
- Odom, Laila
- Odom, Lamar
- Odom Jr., Leslie
- Oduye, Adepero
- Offerman, Nick
- Office Space
- Ogden, Diane
- OGrady, Gail
- OGrady, Lani
- Oh, Angela
- Oh, Sandra
- Ohana, Emilie
- OHara, Catherine
- Ohmart, Carol
- Ohno, Apolo Anton
- Oka, Masi
- Okamura, Gerald
- OKeefe, Jodi Lyn
- Okeniyi, Dayo
- Okina, Megumi
- Okonedo, Sophie
- Okuma, Enuka
- Olbermann, Keith
- Oldfield, Juliet
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- Oldford, Britne
- Oldman, Gary
- Olejnik, Craig
- Oleynik, Larisa
- Olin, Ken
- Olin, Lena
- Olin, Roxy
- Oliver, Barret
- Oliver, Edna May
- Oliver, Jamie
- Oliver, John
- Olivier, Laurence
- Olivieri, Dawn
- Olivo, America
- Olivo, Karen
- Oller, Tony
- Olmos, Edward James
- Olmstead, Gertrude
- Olsen, Ashley
- Olsen, Elizabeth
- Olsen, Eric Christian
- Olsen, Mary-Kate
- Olsen, Mary Kate and Ashley
- Olsen, Susan
- Olson, Bree
- Olson, Heather Lauren
- Olson, Kaitlin
- Olsson, Ty
- Olyphant, Timothy
- Omahyra
- Omarosa
- Omundson, Timothy
- Onal, Funda
- Oneale, Charlie
- ONeil, Nance
- ONeil, Sally
- Ontiveros, Lupe
- Ontkean, Michael
- Onweagba, Oluchi
- Oosterhouse, Carter
- Orbach, Jerry
- Ordon, Julie
- Ordonez, Magglio
- Ordway, Melissa
- Oreiro, Natalia
- Orman, Suze
- Ormond, Julia
- ORourke, Heather
- Orr, Ashley Rose
- Orser, Leland
- Ortega, Kenny
- Ortiz, Ana
- Ortiz, Carla
- Ortiz, David
- Ortiz, Janelle
- Ortiz, John
- Ortiz, Russ
- Ortiz, Shalim
- Ortiz, Tito
- Ortiz, Valery
- Ortiz, Victor
- Ortiz-Magro, Ronnie
- Orton, Kyle
- Orton, Randy
- Orwell, George
- Osborne, Marie
- Osbourne, Jack
- Osbourne, Sharon
- Osmanski, Joy
- Osment, Emily
- Osment, Haley Joel
- Osmond, Ken
- Osmond, Marie
- Osnes, Laura
- Osteen, Joel
- Ostriche, Muriel
- Ostrom, Meredith
- Ostrosky, Beth
- Ostrum, Peter
- OSullivan, Maureen
- Oswalt, Patton
- Oswalt, Roy
- Oteri, Cheri
- Otis, Carre
- Otto, Miranda
- Ouellet, Maryse
- Outerbridge, Peter
- Outhwaite, Tamzin
- Ovenden, Julian
- Overstreet, Chord
- Overton, Kelly
- Overton, Rick
- Owen, Chris
- Owen, Clive
- Owen, Lloyd
- Owen, Seena
- Owen, Stefania
- Owens, Chris
- Owens, Gary
- Owens, Geoffrey
- Owens, Terrell
- Oxenberg, Catherine
- Oyelowo, David
- Oz, Dr. Mehmet
- Oz, Frank
- Ozsan, Hal
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