The actress, who was a TV hit as Dr. Lilith Sternin in Cheers and its Frasier Crane spin-off, will play the chief of staff in Madam Secretary, a new pilot which features Tea Leoni as an embattled U.S. Secretary of State.
The project by Hall, who also created Joan of Arcadia, will mark Neuwirth's first major main cast role since Law & Order: Trial by Jury, which ran between 2005 and 2006.
Neuwirth has had more recent recurring roles in The Good Wife and Blue Bloods.
The Schindler's List star is strongly opposed to New York Mayor Bill de Blasio's plan to introduce legislation outlawing the popular tourist attraction near Central Park.
Neeson is adamant that mounts do not suffer from working in the city, and he fears the bill will rob carriage drivers of their livelihood.
However, a spokesman for Ireland's national animal rights group, Animal Rights Action Network (ARAN), has taken a...