According to the Hollywood Reporter, Biel will play "the hottest scientist in the world" in an episode for the comedy's upcoming fourth season.
Her character will go head-to-head with Zooey Deschanel's character Jess Day as they both set their sights on the same man at a wedding.
The upcoming season of "New Girl" premieres on Tuesday, Sept. 16. Biel's TV resume includes seven seasons on "7th Heaven."
Biel has starred in films including "The A-Team," "Total Recall" and "New Year's Eve."
While the singer's latest album, "Ultraviolence," features a track titled "F---ed My Way Up To The Top," Del Rey says that's not the path that took her to the top of the charts.
"It's commentary, like, 'I know what you think of me,' and I'm alluding to that," she says of the song, admitting that she did seek that kind of, er, 'help,' to land a deal.