The actresso explained the science behind it, saying, "You know, it actually can happen. I mean, the chances of it happening are very rare, but it can happen actually. Which is crazy. Not that it - the chances of it are, like, you know, it's like probably pigs could fly.
"Like, I don't think pigs could fly, but actually sharks could be stuck in tornados," she adds. "There could be a sharknado."
According to the Hollywood Reporter, Biel will play "the hottest scientist in the world" in an episode for the comedy's upcoming fourth season.
Her character will go head-to-head with Zooey Deschanel's character Jess Day as they both set their sights on the same man at a wedding.
The upcoming season of "New Girl" premieres on Tuesday, Sept. 16. Biel's TV resume includes seven seasons on "7th Heaven."
Biel has starred in films including "The A-Team," "Total Recall" and "New Year's Eve."