- Iacono, Paul
- Iannucci, Armando
- Idle, Eric
- Ifans, Rhys
- Iglesias, Gabriel
- Iler, Robert
- Imperioli, Michael
- Inarritu, Alejandro Gonzalez
- Indelicato, Mark
- Infante, Pedro
- Ingels, Marty
- Ingram, Dustin
- Inman, John
- Irby, Michael
- Irigoyen, Adam
- Irons, Jeremy
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- Irons, Max
- Ironside, Michael
- Irvine, Jeremy
- Irwin, Bill
- Irwin, Steve
- Irwin, Tom
- Isaac, Oscar
- Isaacs, Jason
- Iscove, Robert
- Iseya, Yusuke
- Isfeld, Justin
- Issacs, Jason
- Itzin, Gregory
- Ivanek, Zeljko
- Ivanir, Mark
- Izzard, Eddie
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